Simparica Trio Chewable Tablets contain Moxidectin, Pyrantel Embonate and Sarolaner and are used for the treatment of dogs with, or at risk from, mixed external and internal parasitic infestations.
Simparica Trio is exclusively indicated when use against ticks or fleas and gastrointestinal nematodes is indicated at the same time. The veterinary medicinal product also provides concurrent efficacy for the prevention of heartworm disease and angiostrongylosis (lungworm).
- Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
- Ticks and fleas need to start feeding on the host to become exposed to sarolaner; therefore, the transmission of infectious parasite-borne diseases cannot be excluded.
- In the absence of available data, treatment of puppies less than 8 weeks of age and/or dogs less than 1.25 kg bodyweight should be based on a benefit-risk assessment by the responsible veterinarian.
The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed.
The safety of Simparica Trio has not been established during pregnancy and lactation or in dogs intended for breeding. The use in these animals is not recommended.
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